• P. P. Physiotherapy center Larnaca

  • Prodromina Petrou

  • Spasticity (from Greek spasmos-, meaning "drawing, pulling") is a feature of altered skeletal muscle performance with a combination of paralysis, increased tendon reflex activity and hypertonia. It is also colloquially referred to as an unusual "tightness", stiffness, or "pull" of muscles. Clinically, spasticity results from the loss of inhibition of motor neurons, causing excessive muscle contraction. This ultimately leads to an hyperreflexia, an exaggerated deep tendon reflex. Spasticity is often treated with the drug baclofen, which acts as an agonist at GABA receptors, which are inhibitory and contribute to its efficacy as an antispasticity agent. Spastic cerebral palsy is the most common form of cerebral palsy, which is group of permanent movement problems that do not get worse over time. GABA's inhibitory actions contribute to GABA's efficacy as an anti-spasticity agent.